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Istaroxime hydrochloride

Name: Istaroxime hydrochloride
Brand: TargetMol
SKU: T15599
Rating: 4.5 (1 reviews)

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Catalog No. T15599Cas No. 374559-48-5

Alias ST-2744 hydrochloride, PST-2744 hydrochloride, PST2744 hydrochloride, PST 2744 hydrochloride, Istaroxime HCl

Istaroxime hydrochloride (PST2744 hydrochloride) is a Na+/K+-ATPase inhibitor and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator, a novel positive inotropic compound that can be used to study acute heart failure.

Istaroxime hydrochloride

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Catalog No. T15599Alias ST-2744 hydrochloride, PST-2744 hydrochloride, PST2744 hydrochloride, PST 2744 hydrochloride, Istaroxime HClCas No. 374559-48-5

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$134	5 days	5 days
5 mg	$229	5 days	5 days
10 mg	$376	5 days	5 days
50 mg	$789	6-8 weeks	6-8 weeks
100 mg	$1,180	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$252	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Istaroxime hydrochloride (PST2744 hydrochloride) is a Na+/K+-ATPase inhibitor and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator, a novel positive inotropic compound that can be used to study acute heart failure.
Targets&IC50	Na+, K+-ATPase:0.11 μM, Na+, K+-ATPase (guinea-pig kidney):8.5 μM, Na+, K+-ATPase (dog kidney):0.43 μM
In vitro	Istaroxime hydrochloride acts as a positive inotropic drug by inhibiting Na+,K+-ATPase. [1] The IC50 value of Istaroxime hydrochloride for inhibition of Na+/K+-ATPase activity in dog kidney was 0.43 μM. In guinea-pig kidney tissue preparations, the potency of Istaroxime hydrochloride for inhibition of Na+/K+-ATPase activity was 8.5 μM. [2]
In vivo	Istaroxime hydrochloride progressively elevated +dP/dtmax throughout the infusion period, achieving an 80% effect at a cumulative dose of 1.89 ± 0.37 mg/kg (ED80) and reaching a peak effect of 140 ± 3.5% at a dose increase to 4.88 ± 0.6 mg/kg (EDmax). [2]
Synonyms	ST-2744 hydrochloride, PST-2744 hydrochloride, PST2744 hydrochloride, PST 2744 hydrochloride, Istaroxime HCl

Chemical Properties

Molecular Weight	396.95
Formula	C₂₁H₃₃ClN₂O₃
Cas No.	374559-48-5
Smiles	C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)C(=O)CC4)[H])(CC(=O)[C@]1(CC(=NOCCN)CC2)[H])[H])[H].Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (50.38 mM), Sonication is recommended.

DMSO: 40 mg/mL (100.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.04 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5192 mL	12.5960 mL	25.1921 mL	125.9604 mL
5 mM	0.5038 mL	2.5192 mL	5.0384 mL	25.1921 mL
10 mM	0.2519 mL	1.2596 mL	2.5192 mL	12.5960 mL
20 mM	0.1260 mL	0.6298 mL	1.2596 mL	6.2980 mL
50 mM	0.0504 mL	0.2519 mL	0.5038 mL	2.5192 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0252 mL	0.1260 mL	0.2519 mL	1.2596 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc